Study type: Human research · Status: Verified against declared source

The Human Cathelicidin Antimicrobial Chemical sequence LL-37 and Mimics are Potential Anticancer Drugs

2015

Study scale: Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial pathogens in many organisms.

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Cancer is a major world health problem, and it is predicted that there will be approximately 26 million new cancer cases and 17 million cancer-related deaths annually by 2030 (38).

Scale or participants

Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial pathogens in many organisms.

Key findings

Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial pathogens in many organisms.

Limitations and uncertainty

LL-37 has a net positive charge of +6 at a physiological pH, a hydrophobic N-terminal domain, and an α-helical conformation that is most pronounced in the presence of negatively charged lipids (6).

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.