Study type: In vivo/preclinical · Status: Verified against declared source

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention.

Nature communications · 2019

Study scale: Following acquisition of baseline performance, rats were assigned to the testing phase where the task comprised 100 consecutive trials with a random assignment of laser-ON or laser-OFF trials.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Further information on research design is available in the Nature Research Reporting Summary linked to this article.

Scale or participants

Following acquisition of baseline performance, rats were assigned to the testing phase where the task comprised 100 consecutive trials with a random assignment of laser-ON or laser-OFF trials.

Key findings

Next, in the same recordings, we induced APs in presynaptic ChAT-VIP neurons by activating ChR2 with brief blue-light pulses (Fig.

Limitations and uncertainty

The neurotransmitter acetylcholine (ACh) shapes activity of cortical neurons and supports cognitive functions such as learning, memory and attention1–3.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.