Study type: In vitro · Status: Verified against declared source
A stable cyclized antimicrobial chemical sequence derived from LL-37 with host immunomodulatory effects and activity against uropathogens.
Cellular and molecular life sciences : CMLS · 2022
Study scale: Annually, over 150 million cases of urinary tract infections (UTIs) occur, with an increasing number of multidrug-resistant strains hampering antibiotic treatment.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
The design, structure, and mechanism of action of CD4-PP.
Methods
The increasing antibiotic resistance among uropathogenic bacteria warrants alternative therapeutic strategies.
Scale or participants
Annually, over 150 million cases of urinary tract infections (UTIs) occur, with an increasing number of multidrug-resistant strains hampering antibiotic treatment.
Key findings
The increasing antibiotic resistance among uropathogenic bacteria warrants alternative therapeutic strategies.
Limitations and uncertainty
In contrast to NMR, analysis via circular dichroism (CD) spectroscopy revealed secondary structure characteristics.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.