Study type: In vivo/preclinical · Status: Verified against declared source
Therapeutic effect of vasoactive intestinal chemical sequence on form-deprived amblyopic kittens.
BMC ophthalmology · 2019
Study scale: At 6 weeks of age, there were significant differences in P100 wave latency and amplitude and VIP immunohistochemistry and in situ hybridization between the control group and the deprivation group (P < 0.05).
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
The purpose of this study was to explore the role of VIP in the LGBd of kittens in visual development.
Methods
Arden et al.
Scale or participants
At 6 weeks of age, there were significant differences in P100 wave latency and amplitude and VIP immunohistochemistry and in situ hybridization between the control group and the deprivation group (P < 0.05).
Key findings
Exploring the role of vasoactive intestinal peptide (VIP) in the lateral geniculate body (LGBd) in visual development and studying the therapeutic effect of VIP on amblyopic kittens.
Limitations and uncertainty
However, due to the short intervention time of VIP in this experiment, the full pharmacological effect of VIP may not have been observed; the P100 latency and amplitude in the VIP intervention group remained significantly different from those in the normal control group.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.