Study type: In vitro · Status: Verified against declared source
Vasoactive intestinal chemical sequence inhibits TNF-alpha-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands.
Arthritis research & therapy · 2009
Study scale: We presented evidence to indicate that acinar cells isolated from submandibular glands of NOD mice with salivary dysfunction are more sensitive to TNF-α-induced apoptotic events than BALB/c control cells and that VIP prevents these effects.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
The aim of the present study was to analyse apoptotic events involving TNF-α/TNF-αR in isolated acini from NOD mice submandibular glands and to explore the ability of VIP to modulate these effects.
Methods
The role of apoptosis of secretory epithelium as a triggering factor of early dysfunction and autoimmune response has been explored in patients with Sjögren's syndrome and in the pre-diabetic NOD mouse model.
Scale or participants
We presented evidence to indicate that acinar cells isolated from submandibular glands of NOD mice with salivary dysfunction are more sensitive to TNF-α-induced apoptotic events than BALB/c control cells and that VIP prevents these effects.
Key findings
The role of apoptotic secretory epithelium as a pro-inflammatory triggering factor of exocrine dysfunction is currently explored in Sjogren's syndrome patients and in the nonobese diabetic (NOD) mouse model.
Limitations and uncertainty
Our conclusions are based on three main observations.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.