Study type: Human research · Status: Verified against declared source

Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived chemical sequences: Implications for age-related macular degeneration.

Redox biology · 2020

Study scale: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in individuals over age 55 in the United States [1].

Abstract only: Open source record

Product or molecular entity relationships

  • Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
  • MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

The authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Scale or participants

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in individuals over age 55 in the United States [1].

Key findings

The mitochondrial-derived peptides (MDPs) are a new class of small open reading frame encoded polypeptides with pleiotropic properties.

Limitations and uncertainty

No such effective treatments are currently available for the more common “dry” AMD, other than supplementation of antioxidants plus zinc, which was shown by the Age-Related Eye Disease Study (AREDS) to slow AMD progression (AREDS, 2001).

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.