Study type: Human research · Status: Verified against declared source
The human 3-residue chemical sequence GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.
Oxidative medicine and cellular longevity · 2012
Study scale: Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions.
Abstract only: Open source record
Product or molecular entity relationships
- GHK-Cu: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions.
Methods
The molecular structure of the GHK copper complex (GHK-Cu) has been extensively studied using X-ray crystallography, EPR spectroscopy, X-ray absorption spectroscopy, and NMR spectroscopy as well as other methods such as titration.
Scale or participants
Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions.
Key findings
Today the most widespread neurological problems are considered neurodegenerative diseases of aging such as Alzheimer's and Parkinson's that rob people from their golden years causing early debilitation and dependency on special care.
Limitations and uncertainty
Since the importance of oxidative stress in the development of age-related neurodegeneration is well established, a number of antioxidant compounds are considered promising in prevention of neurodegenerative disorders, including vitamin E, melatonin, green tea polyphenols, resveratrol, and others [4].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.