Study type: In vitro · Status: Verified against declared source
The human cathelicidin chemical sequence LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment
2022
Study scale: PDAC cells were treated with LL-37 (0, 8 and 16 μM) for 24 h in 6-well plates (0.7 × 103 cells/well) and incubated in DMEM supplemented with 10% FBS plus 1% penicillin and streptomycin.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
The effect of LL-37 on M2 macrophage polarization was determined as described in our previous study, with slight modifications (Zhang et al., 2020).
Scale or participants
PDAC cells were treated with LL-37 (0, 8 and 16 μM) for 24 h in 6-well plates (0.7 × 103 cells/well) and incubated in DMEM supplemented with 10% FBS plus 1% penicillin and streptomycin.
Key findings
Pancreatic cancer is amongst the most lethal malignancies, while its poor prognosis could be associated with promotion of autophagy and the tumor immune microenvironment.
Limitations and uncertainty
Pancreatic cancer is amongst the most lethal malignancies, while its poor prognosis could be associated with promotion of autophagy and the tumor immune microenvironment.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.