Study type: In vivo/preclinical · Status: Verified against declared source

The antimicrobial chemical sequence cathelicidin protects mice from Escherichia coli O157:H7-mediated disease.

PloS one · 2012

Study scale: To test the sensitivity of wild-type (N = 4) and Camp−/− (N = 3) mice for the major E.

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The aim of this study was to investigate the effects of cathelicidin on E.

Methods

The minimal inhibitory concentrations (MIC) and 50% bactericidal concentrations (IC50) were determined using E.

Scale or participants

To test the sensitivity of wild-type (N = 4) and Camp−/− (N = 3) mice for the major E.

Key findings

This study investigated the role of the antimicrobial peptide cathelicidin in Escherichia coli O157:H7 infection and subsequent renal damage.

Limitations and uncertainty

This study investigated the role of the antimicrobial peptide cathelicidin in Escherichia coli O157:H7 infection and subsequent renal damage.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.