Study type: In vivo/preclinical · Status: Verified against declared source

The GBS PI-2a pilus is required for virulence in mice neonates.

PloS one · 2011

Study scale: Immunoblots of cell-wall protein extracts of GBS and recombinant L.

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

These results question the previously described role of PilB pilus in resistance to the host immune defenses.

Methods

The MICs (µg/ml) of S.

Scale or participants

Immunoblots of cell-wall protein extracts of GBS and recombinant L.

Key findings

In this study, the role of the major pilin subunit PilB was tested in systemic virulence using 6-weeks old and newborn mice.

Limitations and uncertainty

We also demonstrated that NEM316 PilB is dispensable for entry and survival within two different mouse-derived macrophage-like cell lines, RAW 264.7 (Fig.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.