Study type: Human research · Status: Verified against declared source
Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases
2012
Study scale: Mutations in a number of specific genes have been associated with familial PD.
Abstract only: Open source record
Product or molecular entity relationships
- Glutathione: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme activities are increasingly implicated in the induction and progression of neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s diseases, amyotrophic lateral sclerosis, and Friedreich’s ataxia.
Methods
Not reported in the reviewed source.
Scale or participants
Mutations in a number of specific genes have been associated with familial PD.
Key findings
GSH is synthesized in cells, with intracellular concentrations ranging from 0.2 to 10 mM [1].
Limitations and uncertainty
Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme activities are increasingly implicated in the induction and progression of neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s diseases, amyotrophic lateral sclerosis, and Friedreich’s ataxia.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.