Study type: In vitro · Status: Verified against declared source

Roles of Neuroactive chemical sequences, VIP and AVP, in the Mammalian Central Circadian Clock

Frontiers in Neuroscience · 2021

Study scale: Creatures on earth anticipate cyclic changes in the surrounding environment, such as day–night, seasonal, and annual changes, to adapt their own physiological functions so that they can minimize risks to survival.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

VIP and gamma aminobutyric acid (GABA) signaling work synergistically to sustain circadian phase differences in the SCN.

Scale or participants

Creatures on earth anticipate cyclic changes in the surrounding environment, such as day–night, seasonal, and annual changes, to adapt their own physiological functions so that they can minimize risks to survival.

Key findings

In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus.

Limitations and uncertainty

Taking advantage of bioluminescence reporters, circadian rhythms can be recorded in individual SCN cells.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.