Study type: Human research · Status: Evidence verified by machine against declared source
Elevated LL-37/FPR2 Axis and its Regulatory Role for Gingival Fibroblasts in Periodontitis.
International dental journal · 2025
Study scale: Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Public plain-language summary
Some fields are not published, because the text held for them did not answer their heading. The published text is limited to the declared source and preserves reported uncertainty. It does not establish efficacy, safety, suitability, or evidence strength.
Research question
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Study design
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Participants or experimental system
Periodontitis, the sixth most prevalent global disease affecting 50-90% of the population, is characterized by progressive destruction of periodontal tissues, causing gingival recession, periodontal pockets formation, alveolar bone loss, tooth mobility, and eventual tooth loss.1,2 Its pathogenesis involves complex interactions between specific pathogens and host immune responses, leading to irreversible periodontal damage.3 Therefore, it is imperative to elucidate the underlying immune mechanisms to enhance therapeutic approaches for this condition.
Study scale
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Intervention or exposure
Not reported in the declared source.
Comparator
Fifty-seven periodontitis patients and fifty-seven healthy controls were included to assess the levels of LL-37 and FPR2 in gingival tissues, gingival crevicular fluid and GFs, as well as to assess their correlation with disease progression.
Outcomes examined
The publicly available GEO dataset GSE1613438 was obtained from the National Center of Biotechnology Information for analyzing the expression of LL-37 and FPR2 in healthy and inflamed gingival tissues.
Key findings
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Limitations and uncertainty
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Product relevance and evidence boundary
This record is a published study, held here with its citation and review status. It is not a statement that any catalog item is effective, safe, or suitable for any use, and nothing in it is a dose or a protocol.
Evidence verified by machine against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.