Study type: Human research · Status: Verified against declared source
Elevated LL-37/FPR2 Axis and its Regulatory Role for Gingival Fibroblasts in Periodontitis.
International dental journal · 2025
Study scale: Gingival fibroblasts (GFs), as the predominant cellular constituents of gingival connective tissue, serve dual roles as both structural components and active participants in immune regulation during periodontitis pathogenesis.4, 5, 6 Positioned at the oral mucosal interface, GFs serve as the first cellular defense against bacterial invasion.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
LL-37, an antimicrobial peptide with dual pro-/anti-inflammatory roles, has been implicated in the pathogenesis of periodontitis, yet its specific action through its receptor Formyl peptide receptor 2 (FPR2) remains unclear.
Methods
Patients with periodontitis who underwent periodontal flap surgery and healthy individuals with impacted teeth intended for extraction were enrolled in our study.
Scale or participants
Gingival fibroblasts (GFs), as the predominant cellular constituents of gingival connective tissue, serve dual roles as both structural components and active participants in immune regulation during periodontitis pathogenesis.4, 5, 6 Positioned at the oral mucosal interface, GFs serve as the first cellular defense against bacterial invasion.
Key findings
LL-37, an antimicrobial peptide with dual pro-/anti-inflammatory roles, has been implicated in the pathogenesis of periodontitis, yet its specific action through its receptor Formyl peptide receptor 2 (FPR2) remains unclear.
Limitations and uncertainty
LL-37, the sole human cathelicidin antimicrobial peptide, is mainly produced by phagocytic leukocytes and epithelial cells.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.