Study type: In vitro · Status: Verified against declared source

Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37.

Respiratory research · 2019

Study scale: Not reported

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs).

Methods

Calu-3 cells cultured at the air-liquid interface were pretreated with or without GCSs, LABAs, GCSs plus LABAs, or LL-37, and subsequently exposed to CSE.

Scale or participants

Not reported in the reviewed source.

Key findings

Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs).

Limitations and uncertainty

CSE caused airway epithelial barrier dysfunction and simultaneously downregulated multiple TJ and AJ proteins.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.