Study type: In vivo/preclinical · Status: Verified against declared source
Plasma hormones facilitated the hypermotility of the colon in a chronic stress rat model.
PloS one · 2012
Study scale: The number of fecal pellets during 1 h of acute restraint stress and the plasma hormones levels of substance P (SP), thyrotropin-releasing hormone (TRH), motilin (MTL), and cholecystokinin (CCK) in WAS rats were significantly increased compared with SWAS rats, whereas vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and corticotropin releasing hormone (CRH) in WAS rats were not significantly changed and peptide YY (PYY) in WAS rats was significantly decreased.
Abstract only: Open source record
Product or molecular entity relationships
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Plain-language verified summary
Question
In our present study, the WAS rats had higher levels of SP, TRH, MTL and CCK in plasma and lower levels of PYY when compared with SWAS rats.
Methods
For the terminal effect of these peptides and hormones on motor function, permeability and sensitivity, either directly or indirectly, ion channels play an important role, such as in controlling the manner and extent of colonic motility [26].
Scale or participants
The number of fecal pellets during 1 h of acute restraint stress and the plasma hormones levels of substance P (SP), thyrotropin-releasing hormone (TRH), motilin (MTL), and cholecystokinin (CCK) in WAS rats were significantly increased compared with SWAS rats, whereas vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and corticotropin releasing hormone (CRH) in WAS rats were not significantly changed and peptide YY (PYY) in WAS rats was significantly decreased.
Key findings
The number of fecal pellets during 1 h of acute restraint stress and the plasma hormones levels of substance P (SP), thyrotropin-releasing hormone (TRH), motilin (MTL), and cholecystokinin (CCK) in WAS rats were significantly increased compared with SWAS rats, whereas vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and corticotropin releasing hormone (CRH) in WAS rats were not significantly changed and peptide YY (PYY) in WAS rats was significantly decreased.
Limitations and uncertainty
However, the mechanism through which stress contributes to colonic motility in IBS patients remains elusive.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.