Study type: In vivo/preclinical · Status: Evidence verified by machine against declared source
Plasma hormones facilitated the hypermotility of the colon in a chronic stress rat model.
PloS one · 2012
Study scale: Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Public plain-language summary
Some fields are not published, because the text held for them did not answer their heading. The published text is limited to the declared source and preserves reported uncertainty. It does not establish efficacy, safety, suitability, or evidence strength.
Research question
To study the relationship between brain-gut peptides, gastrointestinal hormones and altered motility in a rat model of repetitive water avoidance stress (WAS), which mimics the irritable bowel syndrome (IBS).
Study design
The importance of psychological factors was underscored by a recent study that demonstrated significant relief with an open-label placebo given with the strong suggestion that placebos “produce significant mind-body self-healing processes.”
Participants or experimental system
Male Wistar rats were submitted daily to 1-h of water avoidance stress (WAS) or sham WAS (SWAS) for 10 consecutive days.
Study scale
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Intervention or exposure
The weight of the rats was measured every day before exposure to WAS or sham WAS to evaluate weight change from baseline.
Comparator
The plasma of WAS rats (100 µl) decreased the amplitude of spontaneous contractions of controls.
Outcomes examined
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Key findings
The number of fecal pellets during 1 h of acute restraint stress and the plasma hormones levels of substance P (SP), thyrotropin-releasing hormone (TRH), motilin (MTL), and cholecystokinin (CCK) in WAS rats were significantly increased compared with SWAS rats, whereas vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and corticotropin releasing hormone (CRH) in WAS rats were not significantly changed and peptide YY (PYY) in WAS rats was significantly decreased.
Limitations and uncertainty
This study has the following limitations: First, we have not tested whether the changed GI motility is associated with changes in the nervous system including the myenteric nerve plexus, submucosal plexus and rhythm of the interstitial cells of Cajal (ICC) in addition to the association with peptides and hormones.
Product relevance and evidence boundary
This record is a published study, held here with its citation and review status. It is not a statement that any catalog item is effective, safe, or suitable for any use, and nothing in it is a dose or a protocol.
Evidence verified by machine against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.