Study type: In vitro · Status: Verified against declared source

Cytoprotective effect of neuroactive chemical sequences on cancer stem cells: vasoactive intestinal chemical sequence-induced antiapoptotic signaling.

Cell death & disease · 2017

Study scale: As quantification of such a very low number of CSCs in PC cells can make the assay sensitive to confounding effects, and are not sufficient to address our goals that demanded multiple experiments, we enriched CSCs by forming spheres.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Cancer stem cells (CSCs) are increasingly considered to be responsible for tumor initiation, metastasis and drug resistance.

Methods

Not reported in the reviewed source.

Scale or participants

As quantification of such a very low number of CSCs in PC cells can make the assay sensitive to confounding effects, and are not sufficient to address our goals that demanded multiple experiments, we enriched CSCs by forming spheres.

Key findings

Cancer stem cells (CSCs) are increasingly considered to be responsible for tumor initiation, metastasis and drug resistance.

Limitations and uncertainty

VIP binds to VIPR and performs a wide variety of functions in cancer and normal cells.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.