Study type: In vivo/preclinical · Status: Verified against declared source

HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.

Cell death & disease · 2025

Study scale: A Peritonitis was induced in C57/Bl6 mice by intraperitoneal (i.p.) injection of 1 mg zymosan-A (Zy.) resuspended in PBS (open dark blue circles) or vehicle PBS (Veh., black circles).

Abstract only: Open source record

Product or molecular entity relationships

Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

In this work, we performed a global transcriptomic analysis of efferocytic macrophages to unravel new factors involved in the resolution of inflammation in humans.

Methods

In our RNA-seq data, we noticed the strong up-regulation of MTRNR2L12 and MTRNR2L6 genes that are related to the HN gene (MT-RNR2), which encodes for a mitohormesis-associated protein.

Scale or participants

A Peritonitis was induced in C57/Bl6 mice by intraperitoneal (i.p.) injection of 1 mg zymosan-A (Zy.) resuspended in PBS (open dark blue circles) or vehicle PBS (Veh., black circles).

Key findings

Elimination of apoptotic neutrophils by macrophages, a process called efferocytosis, is a critical step in the resolution of inflammation.

Limitations and uncertainty

Clearance of apoptotic neutrophils by phagocytes, a process called efferocytosis, is a critical tipping point for promoting inflammation resolution [1, 2].

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.