Study type: In vivo/preclinical · Status: Verified against declared source

Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis.

Scientific reports · 2018

Study scale: The total numbers of proteins identified in the control, 10 and 50 mgF/L groups were 294, 343 and 322, respectively.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Photomicrography of myenteric neurons of the rats jejunum stained for HuC/D (green), nNOS (red), and double-labeling (HuC/D and nNOS) for the control group (0 mgF/L) and for the groups treated with 10 and 50 mgF/L.

Methods

The Ethics Committee for Animal Experiments of Bauru Dental School, University of São Paulo approved all experimental protocols (#014/2011 and #012/2016).

Scale or participants

The total numbers of proteins identified in the control, 10 and 50 mgF/L groups were 294, 343 and 322, respectively.

Key findings

Gastrointestinal symptoms are the first signs of fluoride (F) toxicity.

Limitations and uncertainty

Fluoride (F) is considered one of the essential elements for the maintenance of the normal cellular processes in the organism1 and is largely employed in dentistry to control dental caries2.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.