Study type: In vitro · Status: Verified against declared source
The protective effect of the mitochondrial-derived chemical sequence MOTS-c on LPS-induced septic cardiomyopathy
2023
Study scale: Mice were obtained from Vital River (Nanjing, China).
Abstract only: Open source record
Product or molecular entity relationships
- MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Septic cardiomyopathy is associated with mechanisms such as excessive inflammation, oxidative stress, regulation of calcium homeostasis, endothelial dysfunction, mitochondrial dysfunction, and cardiomyocyte death, and there is no effective treatment at present.
Methods
Not reported in the reviewed source.
Scale or participants
Mice were obtained from Vital River (Nanjing, China).
Key findings
Septic cardiomyopathy is associated with mechanisms such as excessive inflammation, oxidative stress, regulation of calcium homeostasis, endothelial dysfunction, mitochondrial dysfunction, and cardiomyocyte death, and there is no effective treatment at present.
Limitations and uncertainty
Septic cardiomyopathy is associated with mechanisms such as excessive inflammation, oxidative stress, regulation of calcium homeostasis, endothelial dysfunction, mitochondrial dysfunction, and cardiomyocyte death, and there is no effective treatment at present.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.