Study type: In vivo/preclinical · Status: Verified against declared source

Discovery of novel antibacterial agent for the infected wound treatment: all-hydrocarbon stapling optimization of LL-37.

Theranostics · 2024

Study scale: The limitations of LL-37 have promoted the research on the identification of its bioactive regions.

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Herein, the present study aims to push the frontier of KR-12 optimization by exploiting the all-hydrocarbon stapling strategy.

Methods

Methods: To push the frontiers of its clinical application, all-hydrocarbon stapling strategy was exploited here for the structural modification of KR-12, the core and minimal fragment of LL-37.

Scale or participants

The limitations of LL-37 have promoted the research on the identification of its bioactive regions.

Key findings

Results: Based on a library of KR-12 derivatives that designed and synthesized to be stapled at positions of either i, i+4 or i, i+7, structure to activity relationship was investigated.

Limitations and uncertainty

Rationale: Antimicrobial peptide LL-37 has been recognized as a favorable alternative to antibiotics due to its broad antibacterial spectrum, low resistance development and diverse biological activities.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.