Study type: In vitro · Status: Verified against declared source

Cationic antimicrobial chemical sequences: alternatives and/or adjuvants to antibiotics active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa.

BMC microbiology · 2019

Study scale: This work was, in part, presented orally at the ECCMID 2018 congress (European Congress of Clinical Microbiology and Infectious Diseases) in Madrid, Spain (April, 21–24; presentation number O0253).

Abstract only: Open source record

Product or molecular entity relationships

  • LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The purpose of this study was to investigate the in vitro antibacterial activities of four CAMPs against clinical and laboratory strains of S.

Methods

The incidence of hospital acquired infections due to MDRPA, strains defined as non-susceptible to at least one agent in three or more antimicrobial categories [10], has increased and led to high morbidity and mortality in healthcare settings [11, 12].

Scale or participants

This work was, in part, presented orally at the ECCMID 2018 congress (European Congress of Clinical Microbiology and Infectious Diseases) in Madrid, Spain (April, 21–24; presentation number O0253).

Key findings

Methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa are becoming difficult to treat with antibiotics whereas Cationic Antimicrobial Peptides (CAMPs) represent promising alternatives.

Limitations and uncertainty

In conclusion, CAMA exhibited the highest and broadest spectrum of activity against both Gram-positive and Gram-negative bacteria with no significant differences between strains showing various antibiotic resistance phenotypes.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.