Study type: In vitro · Status: Verified against declared source
The Naturally Occurring Host Defense Chemical sequence, LL-37, and Its Truncated Mimetics KE-18 and KR-12 Have Selected Biocidal and Antibiofilm Activities Against Candida albicans, Staphylococcus aureus, and Escherichia coli In vitro
2017
Study scale: The antibiofilm properties of novel antimicrobials have previously been reported using both the crystal violet assay (Overhage et al., 2008) and the XTT assay (Martinez and Casadevall, 2006), and indeed, the use of more than one bioassay has recently been recommended (Ramage, 2016).
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
Amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products.
Scale or participants
The antibiofilm properties of novel antimicrobials have previously been reported using both the crystal violet assay (Overhage et al., 2008) and the XTT assay (Martinez and Casadevall, 2006), and indeed, the use of more than one bioassay has recently been recommended (Ramage, 2016).
Key findings
Amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products.
Limitations and uncertainty
In terms of generating novel peptides, both combinatorial (He et al., 2010) and rationally designed (Ashby et al., 2016) approaches have been used successfully to produce novel peptide libraries for biological screening.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.