Study type: Human research · Status: Verified against declared source
Oxytocin in metabolic homeostasis: implications for obesity and diabetes management
2018
Study scale: Molecular cloning experiments have confirmed that the human OTR is a member of the rhodopsin‐type class I G‐protein‐coupled receptor superfamily, characterised by seven hydrophobic transmembrane α‐helices joined by alternating intracellular and extracellular loops, with an extracellular N‐terminal domain and a cytoplasmic C‐terminal domain 9, 20, 28.
Abstract only: Open source record
Product or molecular entity relationships
- Oxytocin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Today, synthetic oxytocin (Pitocin/Syntocinon) is regularly prescribed to induce as well as augment labour.
Methods
In human studies, mean overnight serum oxytocin levels were reported to be higher in overweight women compared with healthy normal‐weight controls by Schorr et al.
Scale or participants
Molecular cloning experiments have confirmed that the human OTR is a member of the rhodopsin‐type class I G‐protein‐coupled receptor superfamily, characterised by seven hydrophobic transmembrane α‐helices joined by alternating intracellular and extracellular loops, with an extracellular N‐terminal domain and a cytoplasmic C‐terminal domain 9, 20, 28.
Key findings
Oxytocin was once understood solely as a neuropeptide with a central role in social bonding, reproduction, parturition, lactation and appetite regulation.
Limitations and uncertainty
Oxytocin was first characterised by Sir Henry H.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.