Study type: In vitro · Status: Verified against declared source
Anticancer Effect of Cathelicidin LL-37, Protegrin PG-1, Nerve Growth Factor NGF, and Temozolomide: Impact on the Mitochondrial Metabolism, Clonogenic Potential, and Migration of Human U251 Glioma Cells.
Molecules (Basel, Switzerland) · 2022
Study scale: The data in Table 1, Figure 1B demonstrate that LL-37 (4.0 μM) inhibited 60.3% (p = 0.05) и 43.9% (p = 0.0001) of the clonogenic capability of human glioma U251 cells over 1 day and 2 days, respectively, wherein the percentage of single cells was strongly increased (66.7% and 35.3%) over 1 day and 2 days, respectively, as compared to the control.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Glioblastoma (GBM) is one of the most aggressive and lethal malignancy of the central nervous system.
Methods
Not reported in the reviewed source.
Scale or participants
The data in Table 1, Figure 1B demonstrate that LL-37 (4.0 μM) inhibited 60.3% (p = 0.05) и 43.9% (p = 0.0001) of the clonogenic capability of human glioma U251 cells over 1 day and 2 days, respectively, wherein the percentage of single cells was strongly increased (66.7% and 35.3%) over 1 day and 2 days, respectively, as compared to the control.
Key findings
Glioblastoma (GBM) is one of the most aggressive and lethal malignancy of the central nervous system.
Limitations and uncertainty
There has been a steady growth in morbidity and mortality associated with brain tumors worldwide in the last decade [1].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.