Study type: Human research · Status: Verified against declared source

Vitamin D₃ Status and the Association with Human Cathelicidin Expression in Patients with Different Clinical Forms of Active Tuberculosis.

Nutrients · 2018

Study scale: The study was approved by ethical review boards in Ethiopia including the National Research Ethics Review Committee (NRERC), the Institutional Review Board (IRB) and the AHRI/ALERT Ethics Committee and also by the local ethical review board in Stockholm, Sweden (EPN) (registration numbers 2007/675-31/4 and 2009/1678-31/4).

Abstract only: Open source record

Product or molecular entity relationships

  • LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Despite a well-established role of vitD3 in TB pathogenesis, it is still unknown how 25(OH)D3 levels and LL-37 expression correlate with various forms of clinical TB.

Methods

Despite a well-established role of vitD3 in TB pathogenesis, it is still unknown how 25(OH)D3 levels and LL-37 expression correlate with various forms of clinical TB.

Scale or participants

The study was approved by ethical review boards in Ethiopia including the National Research Ethics Review Committee (NRERC), the Institutional Review Board (IRB) and the AHRI/ALERT Ethics Committee and also by the local ethical review board in Stockholm, Sweden (EPN) (registration numbers 2007/675-31/4 and 2009/1678-31/4).

Key findings

Low vitamin D (vitD3) is one of the most common nutritional deficiencies in the world known to be associated with numerous medical conditions including infections such as tuberculosis (TB).

Limitations and uncertainty

Next, we compared vitD3 status in active TB patients to non-TB controls depending on their TST or HIV status (Figure 2a).

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.