Study type: In vivo/preclinical · Status: Verified against declared source

PACAP and Other Neuroactive chemical sequence Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models.

Molecular & cellular proteomics : MCP · 2019

Study scale: Not reported

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Not reported in the reviewed source.

Key findings

Chronic use of opioids can produce opioid-induced hyperalgesia (OIH), and when used to treat migraine, these drugs can result in increased pain and headache chronicity.

Limitations and uncertainty

Not reported in the reviewed source.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.