Study type: In vitro · Status: Verified against declared source
Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial chemical sequence LL-37.
PLoS pathogens · 2010
Study scale: The relevance of curli and cellulose expression on bacterial adhesion and immune induction in target cells was investigated by the interaction of bacteria with human cells in vitro (Figure 2).
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
To understand the mechanism underlying the more efficient infection by curliated bacteria, we specifically investigated the antimicrobial activity of bladder and renal epithelial cells on adhered bacteria.
Methods
A total of 99 E.
Scale or participants
The relevance of curli and cellulose expression on bacterial adhesion and immune induction in target cells was investigated by the interaction of bacteria with human cells in vitro (Figure 2).
Key findings
Bacterial growth in multicellular communities, or biofilms, offers many potential advantages over single-cell growth, including resistance to antimicrobial factors.
Limitations and uncertainty
Most infections of the urinary tract are caused by uropathogenic E.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.