Study type: Human research · Status: Verified against declared source

Therapeutic Potential of Cathelicidin Chemical sequence LL-37, an Antimicrobial Agent, in a Murine Sepsis Model.

International journal of molecular sciences · 2020

Study scale: The findings suggested that LL-37 administration, intravenously, prevented the upsurge in DAMPs as well as TNF-α, IL-1β and soluble TREM-1 in peritoneal fluids and plasma (Figure 8 and Figure 9).

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Our studies have revealed that LL-37 exhibits multiple functions in sepsis.

Scale or participants

The findings suggested that LL-37 administration, intravenously, prevented the upsurge in DAMPs as well as TNF-α, IL-1β and soluble TREM-1 in peritoneal fluids and plasma (Figure 8 and Figure 9).

Key findings

Among the mechanisms put-up by the host to defend against invading microorganisms, antimicrobial peptides represent the first line.

Limitations and uncertainty

Nearly 30 different cathelicidin types have been described in various species of mammals.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.