Study type: In vitro · Status: Verified against declared source

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection.

Frontiers in immunology · 2020

Study scale: Protein citrullination and PAD activity are important in a number of physiological processes, such as epidermis differentiation, apoptosis, gene transcription or Neutrophil Extracellular Trap (NET) formation (26).

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Previous work from our group, and others, has shown that LL-37 has direct antiviral activity toward HRV viruses (36–38).

Methods

Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections.

Scale or participants

Protein citrullination and PAD activity are important in a number of physiological processes, such as epidermis differentiation, apoptosis, gene transcription or Neutrophil Extracellular Trap (NET) formation (26).

Key findings

Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections.

Limitations and uncertainty

Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.