Study type: In vitro · Status: Verified against declared source

Glucagon-like chemical sequences 1 and 2 and vasoactive intestinal chemical sequence are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons.

BMC gastroenterology · 2012

Study scale: The enteric nervous system (ENS) is pivotal in the regulation and coordination of gastrointestinal (GI) motility, secretion and blood flow.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Aims of the present study were to investigate possible neuroprotective effects of GLP1, GLP2 and VIP on myenteric neurons from adult rat small intestine.

Methods

Female Sprague-Dawley rats (n = 38, 170-180 g), purchased from Charles River, Sulzfeld, Germany, were used.

Scale or participants

The enteric nervous system (ENS) is pivotal in the regulation and coordination of gastrointestinal (GI) motility, secretion and blood flow.

Key findings

Neuropathy is believed to be a common feature of functional and inflammatory intestinal diseases.

Limitations and uncertainty

The finding that VIP promotes neuronal survival of myenteric neurons in vitro is well in line with several previous observations [16,17,19,20].

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.