Study type: In vivo/preclinical · Status: Evidence verified by machine against declared source
Effect of partial hysterectomy on the neurons of the paracervical ganglion (PCG) of the pig.
PloS one · 2021
Study scale: Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Public plain-language summary
Some fields are not published, because the text held for them did not answer their heading. The published text is limited to the declared source and preserves reported uncertainty. It does not establish efficacy, safety, suitability, or evidence strength.
Research question
The present study examines the response of neurons of PCG innervating uterine horn to axotomy caused by partial hysterectomy in the domestic pig animal model.
Study design
Not reported in the declared source.
Participants or experimental system
Autonomic neurons innervating uterine horn is probably the only nerve cell population capable of periodical physiological degeneration and regeneration.
Study scale
Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.
Intervention or exposure
In all animals 5% suspension of fluorescent tracer Fast Blue (FB, (Polysciences, Inc) in the total volume of 50 μl of water was injected into multiple sites spaced evenly on the length of right uterine horn on the side opposite to the ligamentum latum uteri (Fig 1).
Comparator
In remaining 5 animals only sham operation was performed.
Outcomes examined
After axotomy there was a decrease in expression of catecholamine-synthesizing enzymes (TH, DβH) and a strong increase in the galanin expression.
Key findings
Our study showed that virtually all neurons of the porcine PCG innervating uterine horn are adrenergic and we did not confirm that PCG is the source of cholinergic fibers innervating uterine horn of the pig.
Limitations and uncertainty
The study may be an introduction to further studies on the reaction of PCG neurons on inflammation of the uterus and other pelvic organs, caused by various pathological factors such as microbiological, chemical (e.g. toxins) and physical (e.g. ionizing radiation) factors.
Product relevance and evidence boundary
This record is a published study, held here with its citation and review status. It is not a statement that any catalog item is effective, safe, or suitable for any use, and nothing in it is a dose or a protocol.
Evidence verified by machine against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.