Study type: In vivo/preclinical · Status: Verified against declared source

The effect of gum Arabic supplementation on cathelicidin expression in monocyte derived macrophages in mice.

BMC complementary medicine and therapies · 2022

Study scale: Peripheral blood mononuclear cells (PBMC) were isolated from the diluted buffy coat using Ficoll–Paque density gradient (3 ml of Ficoll) was added to the bottom of a15 ml conical tube without touching the side of the tube.

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Gum Arabic (GA) is derived from the exudates of Acacia senegal or Acacia seyal trees.

Methods

The online version contains supplementary material available at 10.1186/s12906-022-03627-9.

Scale or participants

Peripheral blood mononuclear cells (PBMC) were isolated from the diluted buffy coat using Ficoll–Paque density gradient (3 ml of Ficoll) was added to the bottom of a15 ml conical tube without touching the side of the tube.

Key findings

Antimicrobial peptides (AMPs) are important effectors of the innate defense system.

Limitations and uncertainty

In conclusion, the study demonstrated a novel effect of GA, as an inducer for cathelicidin expression.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.