Study type: In vivo/preclinical · Status: Verified against declared source

Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy.

PLoS neglected tropical diseases · 2015

Study scale: All animals used in these experiments were kept and euthanized in accordance with Institutional Animal Care and Use Committee approved protocol number 13-06-2415R (IACUC, Boston Children’s Hospital), and in adherence to the National Research Council’s ‘Guide to the care and Use of Laboratory Animals’.

Abstract only: Open source record

Product or molecular entity relationships

  • VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The discovery of oral rehydration solution (ORS) for the treatment of acute diarrheal disease is considered one of the greatest medical advances of the 20th century [1].

Methods

With respect to potential clinical applications, we note that current FDA approved formulations of CLT are restricted to 1% topical/vaginal creams or solutions, and 10 mg lozenges for the treatment of oropharyngeal candidiasis.

Scale or participants

All animals used in these experiments were kept and euthanized in accordance with Institutional Animal Care and Use Committee approved protocol number 13-06-2415R (IACUC, Boston Children’s Hospital), and in adherence to the National Research Council’s ‘Guide to the care and Use of Laboratory Animals’.

Key findings

Morbidity and mortality from acute diarrheal disease remains high, particularly in developing countries and in cases of natural or man-made disasters.

Limitations and uncertainty

Morbidity and mortality from acute diarrheal disease remains high, particularly in developing countries and in cases of natural or man-made disasters.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.