Study type: Human research · Status: Evidence verified by machine against declared source
Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.
Alzheimer's research & therapy · 2023
Study scale: We studied all remaining 162 plasma samples from the ADEX cohort, sourced from 47 participants in the control group (n = 38 at baseline, n = 43 at 16 weeks), and 48 participants in the exercise group (n = 44 at baseline, n = 37 at 16 weeks).
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Public plain-language summary
The published text is limited to the declared source and preserves reported uncertainty. It does not establish efficacy, safety, suitability, or evidence strength.
Research question
For this purpose, we studied changes in neuroprotective proteins proBDNF, BDNF, and humanin in plasma NDEVs from patients with mild to moderate AD participating in the randomized controlled trial (RCT) of exercise ADEX.
Study design
proBDNF, BDNF, and humanin were quantified in NDEVs immunocaptured from the plasma of 95 ADEX participants, randomized into exercise and control groups, and collected at baseline and 16 weeks.
Participants or experimental system
Exploratorily, we also quantified NDEV levels of putative exerkines known to respond to exercise in peripheral tissues.
Study scale
We studied all remaining 162 plasma samples from the ADEX cohort, sourced from 47 participants in the control group (n = 38 at baseline, n = 43 at 16 weeks), and 48 participants in the exercise group (n = 44 at baseline, n = 37 at 16 weeks).
Intervention or exposure
Multiple clinical trials assessing exercise as a non-pharmacological intervention for AD have found improvements in cognition, neuropsychiatric symptoms, and physical function.
Comparator
Inter-correlations between NDEV biomarkers observed at baseline were maintained after exercise.
Outcomes examined
NDEV levels of putative exerkines remained unchanged.
Key findings
NDEV levels of proBDNF, BDNF, and humanin increased in the exercise group, especially in APOE ε4 carriers, but remained unchanged in the control group.
Limitations and uncertainty
Also, the present study was limited in terms of enrolling a racially and ethnically homogeneous Danish population; future studies should aim to increase cohort diversity to assess the potential effects of racial and ethnic backgrounds and relevant disparities.
Product relevance and evidence boundary
This record is a published study, held here with its citation and review status. It is not a statement that any catalog item is effective, safe, or suitable for any use, and nothing in it is a dose or a protocol.
Evidence verified by machine against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.