Study type: Human research · Status: Verified against declared source
Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.
Alzheimer's research & therapy · 2023
Study scale: proBDNF, BDNF, and humanin were quantified in NDEVs immunocaptured from the plasma of 95 ADEX participants, randomized into exercise and control groups, and collected at baseline and 16 weeks.
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise in Alzheimer’s disease (AD).
Methods
The online version contains supplementary material available at 10.1186/s13195-023-01303-9.
Scale or participants
proBDNF, BDNF, and humanin were quantified in NDEVs immunocaptured from the plasma of 95 ADEX participants, randomized into exercise and control groups, and collected at baseline and 16 weeks.
Key findings
Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise in Alzheimer’s disease (AD).
Limitations and uncertainty
The randomized controlled design of ADEX offers the highest level of clinical evidence, especially given a relatively large N, rigorous inclusion criteria including PET-PiB brain imaging and good adherence [4].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.