Study type: In vivo/preclinical · Status: Verified against declared source
The tri-chemical sequence GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.
Oncotarget · 2016
Study scale: A.
Abstract only: Open source record
Product or molecular entity relationships
- GHK-Cu: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
Acute lung injury (ALI), along with its most severe form, acute respiratory distress syndrome (ARDS), is a disorder of acute inflammation and tissue injury that is characterized by the loss of alveolar-capillary membrane integrity, excessive transepithelial neutrophil migration, and the release of pro-inflammatory and cytotoxic mediators [1, 2].
Scale or participants
A.
Key findings
The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling.
Limitations and uncertainty
The human tripeptide Glycyl-l-histidyl-l-lysine (GHK) is present in the plasma, saliva, and urine and is used for wound treatment and skin care [18].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.