Study type: Human research · Status: Verified against declared source

Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study.

Scientific reports · 2022

Study scale: We obtained early morning blood samples from all participants after they had signed the consent form to participate.

Abstract only: Open source record

Product or molecular entity relationships

Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

We performed spirometry and 6 min walk test (6MWT) according to the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) protocol29,30: patients were asked to walk as far as they can in 6 min in a 30-m straight corridor without any interruption.

Scale or participants

We obtained early morning blood samples from all participants after they had signed the consent form to participate.

Key findings

Mitokines (Humanin (HN), GDF15 and FGF21) are produced as a result of mitochondrial dysfunction and may have major roles in chronic inflammation, malnutrition and exercise capacity in people with COPD.

Limitations and uncertainty

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide1.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.