Study type: In vitro · Status: Verified against declared source

Human antimicrobial chemical sequence LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study.

BMC cardiovascular disorders · 2006

Study scale: Not reported

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Death of smooth muscle cells in the atherosclerotic plaques makes the plaques more prone to rupture, which can initiate an acute ischemic event.

Methods

We investigated the presence of LL-37 in human atherosclerotic lesions obtained at autopsy using immunohistochemistry.

Scale or participants

Not reported in the reviewed source.

Key findings

We investigated the presence of LL-37 in human atherosclerotic lesions obtained at autopsy using immunohistochemistry.

Limitations and uncertainty

This study shows that LL-37 is present in atherosclerotic lesions and that it induces death of vascular smooth muscle cells.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.