Study type: In vivo/preclinical · Status: Verified against declared source

Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer.

Scientific reports · 2020

Study scale: Effect of HN on proliferation and apoptosis of murine TNBC cells.

Product or molecular entity relationships

Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

While the administration of HN and its analogs has shown promising results in preclinical models of degenerative diseases10, the controversy on the role of HN in cancer progression and chemoresistance needs to be addressed before translating these therapeutic approaches to the clinical practice.

Methods

Effect of HN on proliferation and apoptosis of murine TNBC cells.

Scale or participants

Effect of HN on proliferation and apoptosis of murine TNBC cells.

Key findings

Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues.

Limitations and uncertainty

A cytoprotective mitochondrial-derived peptide, humanin (HN), was discovered in healthy neurons of patients suffering Alzheimer’s disease5.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.