Study type: In vitro · Status: Verified against declared source
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction.
Drug design, development and therapy · 2017
Study scale: The study protocol was reviewed and approved by the institutional review board (IRB) of the Changzhi Medical College, People’s Republic of China (IRB number 2015-021453) in accordance with the guidance for the care and use of laboratory animals, issued by the Ministry of Science and Technology of China.
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Not reported in the reviewed source.
Methods
NO was determined by the colorimetric method using a commercial kit (Nanjing Jiangcheng Biological Engineering Company, People’s Republic of China).
Scale or participants
The study protocol was reviewed and approved by the institutional review board (IRB) of the Changzhi Medical College, People’s Republic of China (IRB number 2015-021453) in accordance with the guidance for the care and use of laboratory animals, issued by the Ministry of Science and Technology of China.
Key findings
N-methyl-D-aspartate (NDMA) receptor-mediated excitotoxicity has been implicated in a variety of pathological situations such as Alzheimer’s disease (AD) and Parkinson’s disease.
Limitations and uncertainty
N-methyl-D-aspartate (NDMA) receptor-mediated excitotoxicity has been implicated in a variety of pathological situations such as Alzheimer’s disease (AD) and Parkinson’s disease.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.