Study type: In vivo/preclinical · Status: Verified against declared source
VIP treatment prevents embryo resorption by modulating efferocytosis and activation profile of maternal macrophages in the CBAxDBA resorption prone model.
Scientific reports · 2016
Study scale: Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Recently, Obermajer et al.
Methods
Not reported in the reviewed source.
Scale or participants
Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one.
Key findings
Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one.
Limitations and uncertainty
In the feto-maternal context, VIP is present in viable implantation sites of normal mice where it induces an increase in Treg frequency12.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.