Study type: Human research · Status: Verified against declared source

The Effect of Cerebrolysin on the Predictive Value of Baseline Prognostic Risk Score in Moderate and Severe Traumatic Brain Injury.

Journal of medicine and life · 2020

Study scale: Of the 142 patients enrolled in the CAPTAIN II study, 80 were in the active treatment group.

Product or molecular entity relationships

Cerebrolysin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The aim of the study was to demonstrate the predictive value of the Baseline Prognostic Risk Score (BPRS) in moderate to severe TBI, in a sample of patients treated with neurotrophic factors.

Methods

The initial evaluation of the neurological and general status consisted of three scales: Glasgow Coma Scale (GCS) [22], Abbreviated Injury Scale (AIS) [23], and Baseline Prognostic Risk Factors (BPRS) [15].

Scale or participants

Of the 142 patients enrolled in the CAPTAIN II study, 80 were in the active treatment group.

Key findings

Cognitive dysfunction is a significant complaint among patients after moderate to severe traumatic brain injury (TBI), with devastating consequences on functional recovery and quality of life.

Limitations and uncertainty

Traumatic brain injury remains a significant health issue as 27.08 million new cases are reported each year, according to the Global Burden of Disease Study 2016 [1].

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.