Study type: In vitro · Status: Verified against declared source
Antimicrobial Effects of Thymosin Beta-4 and Ciprofloxacin Adjunctive Therapy in Pseudomonas aeruginosa Induced Keratitis
2020
Study scale: Bacterial keratitis is an extremely debilitating and rapidly progressive infection of the cornea which can advance into sight-threatening consequences including endophthalmitis and corneal opacification.
Abstract only: Open source record
Product or molecular entity relationships
- Thymosin Beta-4 (TB500): Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Overall, our objective was to elucidate the mechanism(s) by which Tβ4 affects bacterial killing, host response, and ciprofloxacin activity in the setting of bacterial keratitis.
Methods
Overall, our objective was to elucidate the mechanism(s) by which Tβ4 affects bacterial killing, host response, and ciprofloxacin activity in the setting of bacterial keratitis.
Scale or participants
Bacterial keratitis is an extremely debilitating and rapidly progressive infection of the cornea which can advance into sight-threatening consequences including endophthalmitis and corneal opacification.
Key findings
Prior work has indicated that thymosin beta 4 (Tβ4) administered with ciprofloxacin markedly improves disease outcome for Pseudomonas aeruginosa (PA)-induced keratitis.
Limitations and uncertainty
Prior work has indicated that thymosin beta 4 (Tβ4) administered with ciprofloxacin markedly improves disease outcome for Pseudomonas aeruginosa (PA)-induced keratitis.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.