Study type: In vitro · Status: Verified against declared source
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
PloS one · 2014
Study scale: Humanin (HN) is a 24-amino acid peptide originally isolated from a cDNA library of surviving neurons of familial Alzheimer’s disease [1].
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
The aim of the present study was to evaluate the expression and action of HN peptides in anterior pituitary cells.
Methods
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells.
Scale or participants
Humanin (HN) is a 24-amino acid peptide originally isolated from a cDNA library of surviving neurons of familial Alzheimer’s disease [1].
Key findings
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells.
Limitations and uncertainty
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.