Study type: In vivo/preclinical · Status: Verified against declared source
Periosteum Metabolism and Nerve Fiber Positioning Depend on Interactions between Osteoblasts and Peripheral Innervation in Rat Mandible.
PloS one · 2015
Study scale: The ALP layer was used as a reference to divide the periosteal zone into juxta-osseous osteogenic and outer non-osteogenic compartments (Fig 1A and 1B).
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
In the mandible periosteum the sympathetic nervous system modulates bone metabolism through its cholinergic (and not adrenergic) pathway.
Methods
Primary osteoblasts were isolated from calvariae of 2- to 3- day-old mixed C57BL/6 mice (Charles River, L’Arbresle, France), expanded for 5 days and re-plated in differentiation medium [growth medium supplemented with 50 μM ascorbic acid, 10 nM dexamethasone and 5 mM beta-glycerophosphate (Sigma St Louis, MO, USA)].
Scale or participants
The ALP layer was used as a reference to divide the periosteal zone into juxta-osseous osteogenic and outer non-osteogenic compartments (Fig 1A and 1B).
Key findings
The sympathetic nervous system controls bone remodeling by regulating bone formation and resorption.
Limitations and uncertainty
The nervous system has emerged as an important regulator of bone metabolism by centrally controlling bone cell activities.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.