Study type: In vitro · Status: Verified against declared source

Antifungal Activity of Human Cathelicidin LL-37, a Membrane Disrupting Chemical sequence, by Triggering Oxidative Stress and Cell Cycle Arrest in.

Journal of fungi (Basel, Switzerland) · 2022

Study scale: The effect of test peptide on membrane integrity of C.

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Our investigation aimed to discover antifungal compounds that act specifically against fungi and further enhance our findings.

Methods

Candida auris is an emerging species of genus Candida that causes invasive infections in humans.

Scale or participants

The effect of test peptide on membrane integrity of C.

Key findings

Candida auris, an evolving multidrug-resistant pathogenic yeast, is known for causing severe invasive infections associated with high mortality rates in hospitalized individuals.

Limitations and uncertainty

In mammals, AMPs belong to 2 families: cathelicidin and defensin; however, hCAP18, LL-37, and FALL39 are few cathelicidin reported in humans and are mainly located in the secondary granules of neutrophils [13,14].

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.