Study type: In vivo/preclinical · Status: Verified against declared source

Different Inhibitory Interneuron Cell Classes Make Distinct Contributions to Visual Contrast Perception.

eNeuro · 2019

Study scale: A small fraction of sessions (19/129) were significantly better fit by the addition of a second slope parameter specific to ChR2 stimulation trials (F test for number of parameters).

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

We located V1 by measuring changes in the intrinsic autofluorescence signal using epifluorescence imaging (Andermann et al., 2011).

Methods

We began optogenetic stimulation experiments after contrast increment detection thresholds were stable.

Scale or participants

A small fraction of sessions (19/129) were significantly better fit by the addition of a second slope parameter specific to ChR2 stimulation trials (F test for number of parameters).

Key findings

Transgenic mice that provide access to PV, SST, or VIP neurons for optogenetic targeting have helped clarify how different sources of inhibition augment stimulus-evoked responses in sensory cortices.

Limitations and uncertainty

Optogenetic stimulation of PV neurons impaired contrast increment detection, resulting in rightward shift of psychometric functions (Fig.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.