Study type: In vivo/preclinical · Status: Verified against declared source

A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury.

Pflugers Archiv : European journal of physiology · 2023

Study scale: Not reported

Product or molecular entity relationships

Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

A prevalent clinical problem including sepsis, shock, necrotizing enterocolitis, and mesenteric thrombosis is intestinal ischemia/reperfusion (I/R) injury.

Methods

Experimental design flowchart

Scale or participants

Not reported in the reviewed source.

Key findings

A prevalent clinical problem including sepsis, shock, necrotizing enterocolitis, and mesenteric thrombosis is intestinal ischemia/reperfusion (I/R) injury.

Limitations and uncertainty

Although it has been claimed that HN guards against I/R damage to the heart and brain tissues, however, its effect on intestinal I/R injury and its associated dysmotility has not been clarified yet.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.