Study type: Human research · Status: Verified against declared source

MOTS-c, the Most Recent Mitochondrial Derived Chemical sequence in Human Aging and Age-Related Diseases.

International journal of molecular sciences · 2022

Study scale: Type 2 diabetes (T2D) causes insulin insufficiency due to targeted tissue resistance [59].

Abstract only: Open source record

Product or molecular entity relationships

MOTS-c: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

Not reported in the reviewed source.

Scale or participants

Type 2 diabetes (T2D) causes insulin insufficiency due to targeted tissue resistance [59].

Key findings

MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome.

Limitations and uncertainty

Mitochondria are dynamic organelles that are responsible for metabolism and the conversion of energy-storing molecules, such as ATP, for the function of the cell [4].

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.