Study type: In vivo/preclinical · Status: Verified against declared source

Sensory neurons regulate stimulus-dependent humoral immunity in mouse models of bacterial infection and asthma.

Nature communications · 2024

Study scale: Sensory neurons sense pathogenic infiltration to drive innate immune responses, but their role in humoral immunity is unclear.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

RNA was isolated from tissues or cells using the inTron Easy spin Total RNA extraction Kit (Boca Scientific 17221), which was reverse transcribed to cDNA with a Tetro cDNA Synthesis Kit (Tetro biosystems NC1352749).

Scale or participants

Sensory neurons sense pathogenic infiltration to drive innate immune responses, but their role in humoral immunity is unclear.

Key findings

Early investigations have shown that B cells respond to exogenous neuropeptides in vitro and can steer the predominant release of specific immunoglobulin33–37.

Limitations and uncertainty

Conversely, during allergy and asthma, vasoactive intestinal polypeptide (VIP)8 and substance P11 release, activate ILC2s8 and dendritic cells11 to increase eosinophilic infiltration8 and mast cell degranulation11.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.