Study type: In vivo/preclinical · Status: Verified against declared source
The Effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens.
Infectious microbes & diseases · 2024
Study scale: Vitamin A and its biologically active derivative, retinoic acid (RA), are important for many immune processes.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Although the requirement of retinoid signaling during neutrophil maturation is well-established, the precise role of RA in mature neutrophils during host-pathogen interactions remains enigmatic.
Methods
Neutrophil migration was evaluated using the transwell method.68 Lower wells of a Corning 24-well transwell plate with 3 μm pores received 500 nM N-formyl methionyl-leucyl phenylalanine (fMLP, Sigma Aldrich) at a final volume of 650 μL.
Scale or participants
Vitamin A and its biologically active derivative, retinoic acid (RA), are important for many immune processes.
Key findings
Vitamin A and its biologically active derivative, retinoic acid (RA), are important for many immune processes.
Limitations and uncertainty
Vitamin A and its biologically active derivative, retinoic acid (RA), are important for many immune processes.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.